ea0029p867 | Endocrine tumours and neoplasia | ICEECE2012
Sala E.
, Ferrante E.
, Verrua E.
, Malchiodi E.
, Ermetici F.
, Filopanti M.
, Ferrero S.
, Zatella M.
, Degli Uberti E.
, Spada A.
, Beck-Peccoz P.
, Verga U.
Introduction: MEN1 is characterized by tumors of parathyroid glands, pituitary and pancreas. Pituitary tumors frequently produce PRL and GH, but acromegaly due to ectopic GHRH secretion has been reported in <1% of cases. Here we present a case of two patients belonging to a MEN1 family (c.207delC; p.P69PfsX118 mutation (ENST00000377313), affected by primary hyperparathyroidism, in association with acromegaly due to ectopic GHRH secretion and bronchial carcinoid, respective...